Ireland make seven changes, with Dan Sheehan captaining the side for the first time in the absence of Caelan Doris, who misses out with a knee injury.
Sheehan replaces the injured Ronan Kelleher at hooker, while Jack Conan comes in for Doris at eight.
Prop Thomas Clarkson makes a first Test start, Jamie Osborne wins a first Six Nations cap at 15, Mack Hansen returns from injury and Garry Ringrose is preferred to Bundee Aki.
Joe McCarthy is also recalled following injury, with James Ryan, Finlay Bealham and Bundee Aki dropping to the bench.
Uncapped Leinster prop Jack Boyle is included in a matchday squad for the first time.
Ireland: 15-Osborne, 14-Hansen, 13-Ringrose, 12-Henshaw, 11-Lowe; 10-S Prendergast, 9-Gibson-Park; 1-Porter, 2-Sheehan (capt), 3-Clarkson, 4-J McCarthy, 5- Beirne, 6-O’Mahony, 7-Van der Flier, 8-Conan.
Replacements: 16-G McCarthy, 17-Boyle, 18-Bealham, 19-Ryan (Leinster), 20-C Prendergast, 21-Murray, 22-Crowley, 23-Aki.