While it might seem convenient to stay near Milan’s most well-known attractions or main train station, given the extensive public transit system and the ease of using it, you’re better off in a neighborhood with a balanced mix of locals and tourists. Neighborhoods such as Porta Romana, Porta Venezia, or Sant’Ambrogio, which are adjacent to the Duomo epicenter, are well-connected and more pleasant, with more amenities such as grocery stores, pharmacies, and interesting shops, bars, and restaurants. From these neighborhoods, it’s a short walk or metro ride to any of Milan’s major attractions, plus you’ll have plenty to see within the neighborhoods themselves, not to mention more opportunities to integrate into a Milanese lifestyle.